Aprotinin at the Interface: Mechanistic Insights and Stra...
2025-10-21
Aprotinin (Bovine Pancreatic Trypsin Inhibitor, BPTI) is redefining the landscape of translational cardiovascular and membrane biophysics research through its precision inhibition of serine proteases such as trypsin, plasmin, and kallikrein. This thought-leadership article synthesizes current mechanistic data, including new findings on red blood cell (RBC) membrane mechanics, with actionable guidance for researchers aiming to navigate the complex interplay of fibrinolysis inhibition, inflammation modulation, and blood loss management. We highlight competitive insights, experimental strategies, and visionary approaches that move beyond conventional product narratives—offering translational researchers a roadmap to next-generation discovery and clinical impact.